VIP
VIP (Vasoactive Intestinal Peptide) dosing information only:
Subcutaneous Injection
Typical daily dose: 50–200 mcg once or twice daily.
Range: Starting 50–100 mcg once daily; standard 100–200 mcg 1–2x daily; up to 200–300 mcg (divided).
Common example (5 mg vial reconstituted in 5 mL bacteriostatic water = 1 mg/mL):
0.2 mg (200 mcg) = 20 units (0.2 mL) on U-100 insulin syringe.
Some protocols: 5 injections per week (not daily).
Frequency: 1–2 times daily or 5x/week.
Reconstitution example (5 mg vial): Add 5 mL bacteriostatic water → 1 mg/mL. – 100 mcg = 10 units (0.1 mL). – 200 mcg = 20 units (0.2 mL).
Duration: 4–8 weeks or longer cycles (e.g., 3 months on / 1 month off).
Key Potential Benefits of VIP
Potent Anti-Inflammatory and Immune Modulation
Strongly suppresses pro-inflammatory cytokines (such as TNF-α, IL-1β, IL-6, and IFN-γ) while promoting anti-inflammatory mediators and regulatory T-cell activity, helping balance innate and adaptive immune responses.
Reduces systemic and localized inflammation in models of autoimmune and chronic inflammatory conditions, supporting resolution without broad immunosuppression.
Contributes to immune tolerance and downregulation of overactive Th1/Th17 pathways, fostering a more regulated inflammatory environment across multiple tissues.
Support for Gastrointestinal Health and Motility
Relaxes smooth muscle in the esophagus, stomach, gallbladder, and intestines while stimulating secretion of water, electrolytes, bicarbonate, and digestive enzymes into pancreatic juice and bile.
Promotes intestinal epithelial barrier integrity, mucus production, and gut motility, aiding in smoother peristalsis and digestive function.
Helps regulate gastric acid secretion and nutrient/water absorption, supporting overall gut homeostasis and comfort in research models of digestive stress.
Vasodilation, Cardiovascular Support, and Improved Circulation
Induces potent vasodilation of blood vessels (including coronary arteries), lowers arterial blood pressure, and enhances blood flow while stimulating cardiac contractility and heart rate in a balanced manner.
Supports improved oxygen delivery, nutrient transport, and tissue perfusion, with potential benefits for cardiovascular efficiency and reduced vascular resistance.
Contributes to better systemic circulation and energy distribution through enhanced glycogenolysis and metabolic support.
Neuroprotection and Cognitive/Neuronal Health
Protects neurons from oxidative stress, inflammation, and apoptosis while promoting neuronal survival, differentiation, and neurogenesis in key brain regions.
Supports synaptic plasticity, neurotransmitter balance, and resilience against neurodegenerative challenges in preclinical models.
Aids in maintaining cognitive function, mood stability, and brain homeostasis through anti-inflammatory effects on microglia and modulation of central nervous system signaling.
Respiratory and Airway Benefits
Relaxes bronchial and tracheal smooth muscle, promoting bronchodilation and improved airflow while supporting pulmonary epithelial protection.
Enhances oxygenation and reduces airway inflammation, contributing to better respiratory function in models of inflammatory lung conditions.
Supports overall lung tissue resilience and clearance mechanisms through combined vasodilatory and anti-inflammatory actions.
Additional Systemic and Regenerative Advantages
Promotes broader tissue repair, wound healing coordination, and metabolic efficiency (including glucose-dependent insulin secretion and energy substrate utilization).
Enhances adaptive responses to stress, supports microbial balance in the gut, and contributes to hormonal and circadian regulation in research settings.
Provides multi-organ benefits through its widespread receptor distribution, enabling complementary effects on inflammation control, secretion, and relaxation across digestive, nervous, cardiovascular, and immune systems.
