top of page
NAD +

NAD +

$100.00Price
Quantity
100mg
500mg
100mg 10 Bottles
500mg Bottles
Purity Grade
Quantity

NAD+ (Nicotinamide Adenine Dinucleotide) dosing information only:

Subcutaneous (SubQ) Injection (Most Common Self-Administered Route)

  • Typical dose: 50–100 mg per injection.

  • Range: Start at 20–50 mg (e.g., 0.1–0.5 mL of 100 mg/mL solution); standard 50–200 mg per session.

  • Frequency: 2–3 times per week (some protocols: daily for 1 week then Mon–Fri only).

  • Titration examples:

    • Start: 20–30 mg (e.g., 0.1–0.3 mL at 100 mg/mL) for 1 week.

    • Increase: To 50–100 mg (0.5–1 mL at 100 mg/mL) 2–3x/week.

    • Maintenance: 50–120 mg 2–3x/week.

  • Reconstitution note (lyophilized vials, e.g., 500 mg): Common concentration 100 mg/mL or 200 mg/mL. Adjust units on U-100 syringe accordingly (e.g., at 100 mg/mL: 0.5 mL = 50 mg = 50 units).

Intramuscular (IM) Injection

  • Typical dose: 50 mg per injection.

  • Frequency: Up to 3 times per week (spaced out).

  • Key Potential Benefits of NAD+

    1. Enhanced Mitochondrial Function and Cellular Energy Production

      • Serves as a critical cofactor in the electron transport chain and Krebs cycle, facilitating efficient ATP generation and supporting mitochondrial biogenesis for higher cellular energy output.

      • Restores declining NAD+ levels associated with age, stress, or metabolic challenges, leading to improved energy metabolism, reduced fatigue, and greater stamina in preclinical and some human models.

      • Promotes metabolic flexibility, allowing better switching between fuel sources (glucose and fatty acids) for sustained vitality and performance.

    2. Activation of Sirtuins and Support for Healthy Aging Processes

      • Acts as a substrate for sirtuins (especially SIRT1 and SIRT3), which regulate gene expression, DNA repair, inflammation control, and cellular stress resistance pathways.

      • Contributes to improved healthspan markers in preclinical models, including better mitochondrial health, reduced oxidative damage, and enhanced resilience to age-related decline.

      • Supports broader anti-aging mechanisms such as improved cellular repair, protein quality control (autophagy), and maintenance of youthful cellular function across tissues.

    3. Improved Metabolic Health and Insulin Sensitivity

      • Enhances insulin signaling and glucose uptake in muscle and other tissues, supporting better glycemic control and reduced features of metabolic syndrome in relevant models.

      • Aids in lipid metabolism, liver fat reduction, and overall energy balance, with some clinical data showing benefits like improved insulin sensitivity in specific populations (e.g., prediabetic individuals via precursors).

      • Contributes to favorable shifts in body composition, energy expenditure, and metabolic efficiency through optimized NAD+-dependent enzymatic activity.

    4. Neuroprotection, Cognitive Support, and Brain Health

      • Boosts neuronal energy supply, synaptic plasticity, and resilience against oxidative stress and inflammation, supporting memory, focus, mental clarity, and cognitive performance in preclinical studies.

      • Promotes neurogenesis and protects against neurodegenerative challenges by activating repair pathways and maintaining mitochondrial function in brain cells.

      • May aid mood stability, stress resilience, and overall brain vitality through enhanced neurotransmitter balance and reduced neuroinflammatory signaling.

    5. DNA Repair, Antioxidant Defense, and Cellular Resilience

      • Serves as a substrate for PARP enzymes involved in DNA damage detection and repair, helping maintain genomic stability under oxidative or environmental stress.

      • Supports antioxidant systems and reduces accumulation of cellular damage, contributing to better tissue repair and recovery from physical or metabolic strain.

      • Enhances overall cellular resilience, with preclinical evidence linking NAD+ restoration to improved outcomes in models of inflammation, injury, and age-related tissue decline.

    6. Cardiovascular, Muscle, and Systemic Tissue Support

      • Improves vascular function, endothelial health, and cardiac energy metabolism in preclinical models, potentially supporting blood flow, blood pressure regulation, and heart resilience.

      • Aids muscle function, exercise capacity, and recovery by optimizing mitochondrial performance and reducing fatigue-related markers.

      • Provides complementary benefits across organs (liver, heart, brain, muscle) through widespread NAD+-dependent pathways, fostering broader physiological balance and regenerative capacity.

bottom of page