MOT-c
Recommended Dosage
Common wellness/research protocol: 5 mg subcutaneously every 5 days (e.g., 4 injections over ~20 days) or 5 mg 2–3 times per week. Some protocols use lower daily dosing (1 mg daily) or start at 5 mg/week with titration.
Other reported ranges: 5–10 mg per injection, 2–3 times weekly; cycles often last 4–6 weeks or 20 days, repeatable 2–3 times per year with breaks. Morning injections (ideally before exercise) are commonly recommended.
Reconstitution example (for a typical 10 mg vial): Add 2 mL bacteriostatic water (yielding ~5 mg/mL). Use an insulin syringe: 5 mg ≈ 1 mL (100 units on U-100). Subcutaneous injection (abdomen or thigh) is the standard route.
Dosing is highly individualized based on goals (metabolic health, fat loss, performance, longevity), body weight, and response—consult a qualified healthcare provider experienced with peptides for personalized guidance. This is for informational purposes only.
Key Potential Benefits of MOTS-c (MOT-c)
Enhanced Mitochondrial Function and Cellular Energy
Acts as a mitochondria-derived peptide that optimizes mitochondrial performance, improving ATP production and metabolic flexibility.
Helps cells efficiently switch between glucose and fat as fuel sources, supporting better energy utilization under stress or during aging.
Functions as an “exercise mimetic,” mimicking some beneficial effects of physical activity at the cellular level.
Improved Insulin Sensitivity and Glucose Regulation
Activates AMPK and other pathways to enhance insulin sensitivity and glucose uptake in skeletal muscle.
Helps prevent or counteract diet-induced insulin resistance and supports stable blood sugar levels.
Contributes to better overall metabolic health and reduced risk of metabolic dysfunction.
Support for Fat Loss and Body Composition
Promotes fat oxidation and reduces fat accumulation, particularly visceral fat, while preserving lean muscle.
Increases energy expenditure and helps regulate appetite and caloric balance indirectly through improved metabolism.
Aids favorable shifts in body composition, especially when combined with training and proper nutrition.
Increased Physical Performance and Endurance
Enhances exercise capacity, stamina, and running performance in research models across different ages.
Supports muscle function, reduces fatigue, and improves recovery by optimizing energy metabolism in skeletal muscle.
Helps maintain muscle quality and performance during aging or periods of inactivity.
Anti-Aging and Longevity Support
Counters age-related declines in mitochondrial function, metabolic flexibility, and physical capacity.
May protect against metabolic disorders, inflammation, and other hallmarks of aging through improved cellular homeostasis.
Promotes broader healthspan benefits by supporting energy balance and stress resilience.
Broader Metabolic and Systemic Resilience
Supports liver health by reducing fat accumulation and improving metabolic markers.
Exhibits potential anti-inflammatory and cytoprotective effects across tissues.
Enhances overall vitality, energy levels, and physiological resilience as part of longevity or performance protocols.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a 16-amino-acid peptide naturally encoded by mitochondrial DNA. It plays a key role in regulating metabolism and has gained attention for its exercise-like effects.
