LL37
Typical Dosing Protocols (Research/Compounded Use Only) – LL-37
Common protocol: 100–200 mcg subcutaneously once daily for 10–20 consecutive days. Most users start at 100 mcg daily for the first 5–7 days then increase to 150–200 mcg if tolerated.
Other reported ranges:
Standard: 100–200 mcg daily
Intensive: 200–300 mcg daily (for short periods only)
Cycles: Typically 10–20 days on, followed by a minimum 2–4 week break. Some protocols use 5 days on / 2 days off.
Reconstitution example (for a typical 5 mg vial): Add 2 mL bacteriostatic water (yielding ~2.5 mg/mL).
100 mcg = 0.04 mL (4 units on U-100 insulin syringe)
200 mcg = 0.08 mL (8 units)
Administration: Subcutaneous injection (abdomen or thigh). Some users also apply topically (after reconstitution) for localized skin or wound support.
Dosing is highly individualized based on goals (immune support, antimicrobial, wound healing) and response—consult a qualified healthcare provider experienced with peptides for personalized guidance. This is for informational purposes only.
Key Potential Benefits of LL-37
1. Broad-Spectrum Antimicrobial and Immune Defense
Acts as a potent cathelicidin peptide with strong activity against bacteria, viruses, fungi, and some parasites by disrupting microbial membranes.
Supports innate immune responses and helps control infections at mucosal and systemic levels in research models.
2. Wound Healing and Tissue Repair Acceleration
Promotes re-epithelialization, angiogenesis (new blood vessel formation), and granulation tissue development.
Enhances migration and proliferation of keratinocytes, fibroblasts, and endothelial cells for faster wound closure.
3. Anti-Inflammatory and Immune Modulation
Balances inflammatory responses by modulating cytokine production and reducing excessive inflammation while maintaining protective immunity.
Supports resolution of chronic inflammation in preclinical studies.
4. Angiogenic and Regenerative Effects
Stimulates new blood vessel formation and improves tissue perfusion.
Contributes to overall tissue regeneration and repair processes.
5. Skin Health and Barrier Function
Supports skin barrier integrity, collagen production, and antimicrobial defense on the skin surface.
May improve skin healing, reduce infection risk, and promote healthier skin in research contexts.
6. Additional Systemic and Gut Support
Shows potential for gastrointestinal protection and modulation of gut microbiota–immune interactions.
May enhance overall immune resilience and tissue homeostasis under stress or injury conditions.
